Cardiology

Division of Cardiology

Noteworthy Publications

Nikpay M, et al. McPherson R (co-senior/corresponding author; also PhD supervisor to lead author); CARDIoGRAMplusC4D Consortium. A comprehensive 1,000 Genomes- based genome-wide association meta-analysis of coronary artery disease. Nat Genet 2015;47(10):1121–30.

Essebag V, Verma A, Healey JS, Krahn AD, Kalfon E, Coutu B, Ayala-Paredes F, Tang AS, Sapp J, Sturmer M, Keren A, Wells GA, Birnie DH; BRUISE CONTROL Investigators. Clinically Significant Pocket Hematoma Increases Long-Term Risk of Device Infection: BRUISE CONTROL INFECTION Study. J Am Coll Cardiol 2016;67(11):1300–1308.

Le May M, van Diepen S, Liszkowski M, Schnell G, Tanguay JF, Granger CB, Ainsworth C, Diodati JG, Fam N, Haichin R, Jassal D, Overgaard C, Tymchak W, Tyrrell B, Osborne C, Wong G. From Coronary Care Units to Cardiac Intensive Care Units: Recommendations for Organizational, Staffing, and Educational Transformation. Can J Cardiol 2016;32(10):1204–1213.

Wells RG, Wei L, Petryk J, Duan Y, Marvin B, Timmins R, Soueidan K, Fernando P, Bensimon C, Ruddy TD. Flow-dependent uptake of I-123-CMICE-013, a novel SPECT perfusion agent, compared to standard tracers. J Nucl Med 2015;56(5):764–770.

Wang HW, Huang BS, Chen A, Ahmad M, White RA, Leenen FH. Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats. Neuroscience 2016;314: 90–105.

Tilokee EL, Latham N, Jackson R, Mayfield AE, Ye B, Mount S, Lam BK, Suuronen EJ, Ruel M, Stewart DJ, Davis DR. Paracrine Engineering of Human Explant-Derived Cardiac Stem Cells to Over-Express Stromal-Cell Derived Factor 1ïƒĄï€ Enhances Myocardial Repair. Stem Cells 2016;34(7):1826–35.

Le May MR, Acharya S, Wells GA, Burwash I, Chong AY, So DY, Glover CA, Froeschl MP, Hibbert B, Marquis JF, Dick A, Blondeau M, Bernick J, Labinaz M. Prophylactic warfarin therapy after primary percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction. JACC Cardiovasc Interv 2015;8(1 Pt B):155–62.

Ohira H, deKemp R, Pena E, Davies RA, Stewart DJ, Chandy G, Contreras-Dominguez V, Dennie C, Mc Ardle B, Klein R, Renaud JM, DaSilva JN, Pugliese C, Dunne R, Beanlands R, Mielniczuk LM. Shifts in myocardial fatty acid and glucose metabolism in pulmonary arterial hypertension: a potential mechanism for a maladaptive right ventricular response. Eur Heart J Cardiovasc Imaging 2015 Jun 9, pii: jev136.

Yang Y, Chen L, Yam Y, Achenbach S, Al-Mallah M, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Cheng VY, Chinnaiyan K, Cury R, Delago A, Dunning A, Feuchtner G, Hadamitzky M, Hausleiter J, Karlsberg RP, Kaufmann PA, Kim YJ, Leipsic J, LaBounty T, Lin F, Maffei E, Raff GL, Shaw LJ, Villines TC, Min JK, Chow BJ. A clinical model to identify patients with high-risk coronary artery disease. JACC Cardiovasc Imaging 2015;8(4):427–34.

 

 

Key Grants

Liu P (PI)—“IGFBP7—A Novel Biomarker, and a Clue to the Pathophysiology of Heart Failure with Preserved Ejection Fraction?” ($595,099 over 5 years)

Derek So (PI)—“Reassessment of Anti-Platelet therapy using InDividualized Strategies— Ticagrelor in Patients with Acute Coronary Syndromes Treated by Coronary Artery Bypass Graft Surgery—A Pharmacodynamic and Clinical Study to Decrease Bleeding Risks and Ischemic Complications – The RAPID-TITRATE CABG study” ($512,179 over 4 years)

Liu P (PI)—“Developing Novel Therapeutic Targets for Heart Failure” ($925,000 for 5 years including $400,000 from Servier)

Tulloch H (PI)—“Neurocognitive outcomes after out-of-hospital cardiac arrest” ($149,644 over 3 years)

Coutinho T—Investigating the pathogenesis and clinical applications of arterial health in cardiovascular diseases ($148,927 over 3 years)

Birnie D (PI)—Cardiac Sarcoidosis in Multi-centre Prospective Cohort ($259,897 over three years, Ranked 85.45% in Committee 1b)

Coutinho T (PI)—Predictors of Disease Progression in Thoracic Aorta Aneurysms: Role of Arterial Stiffness and Hemodynamics ($220,938 over three years, Ranked 96.49% in Committee 1a)

Stewart A (PI)—Mechanisms of coronary artery calcification risk conferred by 9p21.3 genetic variants ($217,740 over 3 years, Ranked 98.04% in Committee Iva)

Hibbert B (Project Leader)—Platelet Biology to Improve Patient Outcomes—from Bedside to Bench and Back ($537,500)

Liu P (Project Leader) Backx P, Beanlands R, Corkum P, deKemp R, Gramolini A, McPherson R, Pezacki J, Rayner K , Valliant J. Centre for Original Medical Target Evaluation and Translation—Accelerating a First in Human Innovation Strategy (COMET-Alpha). ($5.8M)

 

 

Overview

The Division of Cardiology is located geographically at the University of Ottawa Heart Institute and The Ottawa Hospital (TOH) including the General and Riverside Campuses.  The Division provides tertiary care cardiology service for Ottawa and the Champlain Health District with a referral population of greater than 1.5 million people. The Division is the largest within the Department of Medicine. Our division includes not only cardiologists but also lipid, hypertension, and cardiac rehabilitation specialists and PhD scientists. Members have been recognized locally, nationally and internationally for excellence and innovations in clinical care, teaching and scholarship in education as well as basic/translational science and clinical research.

Research

Cardiology research at the Heart Institute encompasses a broad range of clinical and basic/translational research. Peer-reviewed funding for operating grants for clinical research has increased significantly over the last 5 years.  Cardiology has had large CFI infrastructure grants for cardiac imaging and genetics. Personnel funding for investigators and trainees from peer-reviewed sources has also increased significantly as has productivity in terms of number of peer-reviewed papers in high-impact journals.

Education

The Division has a long tradition of exemplary teaching for all levels of trainees, beginning with the example set by Dr. Donald Beanlands, and then Dr. Lyall Higginson and more recently by Dr. Martin Green and Dr. Mike Froeschl.  This commitment to education as a valued endeavor is reflected in the teaching programs delivered by divisional members.

The Postgraduate Cardiology Residency Program underwent external review in January 2010 and was approved for 6 years. There are currently 12 trainees in the program, many of whom come from around the world.  The strengths of the program include:

  1. an effective, supported, dynamic and proactive Program and Divisional leadership;
  2. goals and objectives which are detailed and very functional allowing for easy implementation;
  3. a highly resourced program with a very dedicated faculty; and
  4. a rich academic program with a very enthusiastic teaching staff.

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The Undergraduate Cardiology Teaching Program at the University of Ottawa is divided into preclerkship and clerkship components.  During the former, cardiology is taught with respirology, nephrology and oncology in an 18-week integrated Unit (Unit 1) during the first year in both the English and French language streams.  All members of our Division are wholehearted participants.

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The Core Internal Medicine Program explicitly mandates and provides a robust cardiology experience, both in CCU and ward/ambulatory cardiology. There are ample opportunities to pursue research projects in collaboration with divisional members and such projects often lead to national and international presentations and journal articles.

Patient Care

The Division provides expert clinical care in a broad range of programs in arrhythmia electrophysiology, cardiac imaging including echocardiography, coronary intervention, heart failure and transplantation.  Core clinical facilities at the Heart Institute include 4 catheterization laboratories, 2.5 electrophysiology laboratories, 3 clinical ward services with 68 beds, a coronary care unit with 14 beds, a Day Unit with 25 beds and a Reference Centre with 7 beds.  Basic science laboratories are located in the Heart Institute Research Centre, which is an integral part of the Heart Institute.  The Division also provides outreach care to remote areas including Iqualuit in Baffin Island.  The Division of Cardiology at The Ottawa Hospital (General and Riverside Campuses) clinical facilities includes a ward service and CCU, specialized ambulatory care clinics and noninvasive cardiac imaging.

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Notable Honours and Achievements in Recent Years

Awards

  • Dr. Rob Beanlands—Canadian Cardiovascular Society Research Achievement Award, Department of Medicine Vision Award
  • Dr. David Birnie—University of Ottawa Clinical Research Chair Award (Tier 1)
  • Dr. Thais Coutinho—Canadian Cardiovascular Society Young Investigator Award, HSF Ontario Clinician Scientist Award
  • Dr. Ross Davies—The Ottawa Hospital’s Physician Clinician Recognition Award
  • Dr. Darryl Davis—University of Ottawa Clinical Research Chair Award (Tier 2)
  • Dr. Rob deKemp—European Union Patent for Rubidium PET technology
  • Dr. Lloyd Duchesne—Exemplary Care Recognition from UOHI Nursing
  • Dr. Girish Dwivedi—Canadian Society of Echocardiography Top Abstract Award, CIHR New Investigator Award, CIHR Institute of Muscoloskeletal Health and Arthritis (IMHA) Research Ambassadors Knowledge Translation Award, Junior Clinical Research Chair Award from uOttawa
  • Dr. Nadine Gauthier—Master’s in Education, University of Cincinnati
  • Dr. Lisa Mielniczuk—University of Ottawa Clinical Research Chair Award (Tier 2)
  • Dr. Derek So—HSF Mid-Career Investigator Award
  • Dr. Steven Promislow—2016 PARO Resident Teaching Award

Leadership

  • Duncan Stewart, CEO and Scientific Director, OHRI
  • Ruth McPherson, Chair, the Ruddy Canadian Cardiovascular Genetics Centre
  • Marino Labinaz, Director Cardiac Care Unit (CCU)
  • Michael Froeschl, Education Director for Cardiology (and Residency Training and Fellowship Director)
  • Michele Turek, Site Director of Cardiology, TOH General Campus
  • Nadine Gauthier, Director English and French Cardiovascular Block Program

Location Information

University of Ottawa Heart Institute – 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7

The Ottawa Hospital-General Campus – 501 Smyth Road, Ottawa ON  K1H 8L6