Kudos for February 2014

Quality

Media

Curtis Cooper interviewed by CFRA  and The Ottawa Citizen in regards to an Ottawa woman who needs new treatment for Hep C which is not covered by Ontario’s health care program. The new drugs have a success rate of 90% and although approved by Health Canada have not been accepted by the Ontario provincial government. Dr. Cooper called the new treatment ‘game changing’.

Andrew Pipe is at Socchi Olympics as Chair of the Olympic medical group. He was interviewed by Global News – Doping at the Olympics? Rumblings of new ‘undetectable drug’ surface. Dr. Pipe spoke about “a black market of products” and how the public becomes attuned to these issues and more interested when there is a major international sporting event. The new ‘undetectable doping agent’ is MGF – a therapy that boosts muscle growth. Olympic officials are saying they have “the most stringent measures’ in place and Dr. Pipe was quoted as saying “there is much more coordination and cooperation than there was 5 to 10 years ago.” He also said that ‘Future technology in testing for doping can even be applied to previous blood samples.’ Socchi samples will be shelved for 10 years and if 2024 technology finds an athlete guilty of doping, a 2014 medal can be rescinded.

Mark Tyndall interviewed by CFRA re: Conservative bill to increase hurdles for opening supervised injection sites. If the application process for cities to have a supervised injection site is changed and more documentation is required, Dr. Tyndall was quoted as saying: “it’s going to be a major challenge for Ottawa to get all these things in line.”  He feels that supervised injection sites are “considered part of a continuum of care that includes a range of services from mental health care to housing and more”.

Tony Hakim interviewed by the Ottawa Citizen in a feature they did on the University of Ottawa’s Brain and Mind Research Institute. The institute connects 150 neuroscientists working across the city.

Harry Atkins was featured in a CNN report on Stiff Person Syndrome. The story featured a young woman with this disease. Dr. Atkins has treated 3 patients with the Stiff Person Syndrome by using stem cell transplant with strong doses of chemotherapy to wipe out the person’s immune system. They then return purified bone marrow stem cells to the body. Results have been encouraging but Dr. Atkins “is cautious about saying that stem cell transplantation is the definitive treatment for Stiff Person Syndrome.”

Ed Lemaire has developed 3 Blackberry apps to help clinicians understand how a patient with mobility issues stands and moves in real-world settings such as getting out of a car or walking up a grassy hill. TOHRC Biomechanics Augmented Reality app was recently featured in itbusiness.ca. The other 2 apps are called TOHRC Video Event Recorder and TOHRC Data Logger. He plans to develop these apps for iOS and Android devices as well.

Susan Dent was interviewed by Toronto Star for her work forging a new area of inquiry and practice to understand the relationship between cancer therapies and subsequent heart disease. Article was entitled: Cancer treatments: They can weaken the heart but save your life.

Jeff Turnbull interviewed by troymedia.com for an article entitled U.S., Canadian healthcare systems share some challenges.  Dr. Turnbull quoted as saying ”when it comes to treating heart attacks, stroke, heart failure, and pneumonia we do relatively well. But when you look at the broader indices that measure the inequities, the picture is very different. Our vulnerable populations have rates like the developing world.” The two countries share the increasing burden of providing care for their aging populations.

John Bell’s work in developing oncolytic viruses for the treatment of cancer was featured in Biotechnology Focus magazine.  A world-first clinical trial with a virus called Maraba was part of the story. Derek Jonker will evaluate Maraba in combination with a novel anti-cancer vaccine in a trial starting later this year.

Michael Rudnicki’s discovery of a trigger that turns muscle stem cells into brown fat received attention on a science news website called EurekAlert! This website is operated by the American Association for the Advancement of Science. The news release was entitled: Fighting fat with fat: Stem cell discovery identifies potential obesity treatment. 

Collaboration

Greg Knoll & his team performed their 1000th kidney transplant the last week of January 2014.  Dr. Kitts described this as a remarkable achievement with positive impact on many of our patients’ lives.

Kumanan Wilson led a large, Ontario population-based study which determined that girls have an increased likelihood of reacting to a one-year MMR vaccine and visiting a hospital over boys. The study was published in the journal Vaccine. The findings suggest that there may be important physiological differences between boys and girls that cause different responses to the MMR vaccine.

Rashmi Kothary is studying the role of dystonin-a2 protein in keeping our nerves healthy. His research also helps in the understanding of a rare disease called HSAN-VI which is lethal in infancy and is caused by a mutation in the dystonin gene. The research was published in Human Molecular Genetics.

The Ottawa Model for Smoking Cessation, created by the Heart Institute, has reached an impressive 120,000 smokers across Canada since 2006 through a personalized, best practice tobacco dependence treatment. Andrew Pipe was quoted in the Digital Journal  – “the success behind the Ottawa Model for Smoking Cessation is truly found in the determined teams across Canada that are providing personalized support to smokers who are trying to quit.” Smokers who try to quit with the help of best practice counseling, cessation meds, and follow-up, experience double or triple the success rate with quitting long term.

Accountability

Successful CIHR Operating Grants from Sept 2013 competition:

DE KEMP, Robert A

& Beanlands, Chow, DaSilva, Glover, Klein & Ruddy

Ottawa Heart Institute Research Corporation (Ontario)

Operating Grant

201309

MPI

Translational Imaging of Coronary Endothelial Function with Positron Tomography

$391,460

$0

4 yrs 0 mth

DIMITROULAKOS, Jim

Ottawa Hospital Research Institute

Operating Grant

201309

CBT

Targeting the mevalonate pathway in novel combination based therapeutic approaches

$349,842

$0

3 yrs 0 mth

MARSHALL, Shawn C

Ottawa Hospital Research Institute

Operating Grant

201309

SDA

Candrive Prospective Older Driver Study

$1,386,733

$0

3 yrs 0 mth

PICKETTS, David J

Ottawa Hospital Research Institute

Operating Grant

201309

G

Exploring the role of Atrx at tandem DNA repeats: Implications for developmental disorders

$836,818

$0

5 yrs 0 mth

RUDNICKI, Michael A & L. Megeney & T. Perkins & J. Dilworth

Ottawa Hospital Research Institute

Operating Grant

201309

CBT

Genomic Analysis of Rhabdomyosarcoma Tumor Initiating Cells

$1,207,800

$0

5 yrs 0 mth

TANPHAICHITR, Nongnuj  & J Angel

Ottawa Hospital Research Institute

Operating Grant

201309

CIA

Antimicrobial host defence peptides: their potential use as vaginal contraceptives with anti-HIV properties

$622,391

$0

5 yrs 0 mth

WELCH, Vivian A  &

P. Tugwell

Bruyère Research Institute

Operating Grant

201309

PH1

Improving randomized controlled trials for equity-oriented decisions

$220,442

$0

3 yrs 0 mth

CHASEN, Martin R

Bruyère Research Institute

Operating Grant

201309

PLC

Multimodal Exercise, Nutrition and Anti-inflammatory Treatment For Palliation of Cancer Cachexia: the MENAC study

$373,422

$0

3 yrs 0 mth

LIU, Peter P

Ottawa Heart Institute Research Corporation (Ontario)

Operating Grant

201309

CSB

Novel Regulators of Cardiac Innate Immunity and post MI Remodeling

$654,575

$0

5 yrs 0 mth

TYNDALL, Mark W

& Y. Schreiber &

C. Cooper & L. Balfour

Ottawa Hospital Research Institute

Operating Grant – PA: HIV/AIDS Bridge Funding – Health Services/Pop Hlth Stream

201309

PH1

Prioritizing Community Engagement and Involvement in Understanding HIV Risk among People Who Use Drugs in Ottawa: The PROUD Study

$0

$0

1 yr 0 mth

SQUIRES, Janet E

& J. Grimshaw

University of Ottawa

Operating Grant – Priority Announcement: Knowledge Translation

201309

KTR

Understanding Context in Knowledge Translation: Development and Consensus of a Conceptual Framework

$100,000

$0

1 yr 0 mth

BELL, John C

Ottawa Hospital Research Institute

Proof of Principle Program – Phase I

201309

PPP

Biological Viral Sensitizers for GMP Manufacturing

$123,000

$37,000

1 yr 0 mth

GILL, John S & D. Fergusson & G. Knoll & T. Ramsay

University of British Columbia

Operating Grant

201309

RC1

A Randomized Trial of Screening for Coronary Artery Disease in Kidney Transplant Candidates

$240,252

$0

3 yrs 0 mth

Jim Walker and Dermatology colleagues attended a benefit dinner for Ottawa’s future Dermatology Centre. The dinner was held at the residence of the Irish Ambassador Ray Bassett. The Derm Centre will improve early detection and treatment of skin cancers. Funds from the benefit dinner will go towards the Derm Centre campaign which has raised $2.3 million since May.

Respect

Fraser Scott is being recognized for his diabetes research. He is receiving the Earle W. Crampton Award for Distinguished Service in Nutrition from McGill University for outstanding accomplishments in the area of immunology and gut microbiome and their relation to type 1 diabetes.

Jonathan Angel (Infectious Diseases) and Dar Dowlatshahi (Neurology) have been awarded the first Clinician Scientist Chair Awards from the Research Advisory Committee (RAC) of the Department of Medicine. Dr. Angel receives $200,000 per year for the Senior Clinician Scientist Chair Award and Dr. Dowlatshahi receives $150,000 per year for the New Investigator Award. Both awards are for 2014-2018.

Chris Bredeson, Ed Fitzgibbon and Gianni D’Egidio will be graduating from the Improving Quality & Patient Safety: The Physician Leadership Program on Friday, May 30th, 2014. The event will take place at the Centre for Executive Leadership, World Exchange Plaza, 45 O’Connor St, Suite 350.

Catherine Dubé has been appointed Clinical Lead of the ColonCancerCheck Program. The appointment is effective February 7th, 2014.